Body composition after allogeneic haematopoietic cell transplantation/total body irradiation in children and young people: a restricted systematic review.

ABSTRACT:

Purpose

To collate evidence of changes in body composition following treatment of leukaemia in children, teenagers and young adults (CTYA, 0-24 years) with allogeneic haematopoietic stem cell transplant and total body irradiation (HSCT+TBI).

Methods

Papers were identified by searching Medline and Google Scholar, reference lists/citations and contacting key authors, with no date or language restrictions. Inclusion criteria were as follows: leukaemia, HSCT+TBI, aged ≤ 24 years at HSCT and changes in body composition (total fat, central adiposity, adipose tissue function, muscle mass, muscle function). Quality was assessed using a brief Newcastle-Ottawa scale.

Results

Of 900 papers, 20 were included: seven controlled, five uncontrolled studies and eight case reports. Stu

SUBMITTER: Lorenc A 

PROVIDER: S-EPMC7473918 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature