Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved ¹²⁹Xe MRI.

ABSTRACT: Magnetic resonance (MR) imaging and spectroscopy using dissolved hyperpolarized (HP) ¹²⁹Xe have expanded the ability to probe lung function regionally and noninvasively. In particular, HP ¹²⁹Xe imaging has been used to quantify impaired gas uptake by the pulmonary tissues. Whole-lung spectroscopy has also been used to assess global cardiogenic oscillations in the MR signal intensity originating from ¹²⁹Xe dissolved in the red blood cells of pulmonary capillaries. Herein, we show that the magnitude of these cardiogenic dynamics can be mapped three dimensionally using radial MRI, because dissolved ¹²⁹Xe dynamics are encoded directly in the raw imaging data. Specifically, 1-point Dixon imaging is combined with postacquisition keyhole image reconstru

SUBMITTER: Niedbalski PJ 

PROVIDER: S-EPMC7473944 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature