Serum CXCL13 Level is Associated with Tumor Progression and Unfavorable Prognosis in Penile Cancer.

ABSTRACT:

Background

Chemokine (C-X-C motif) ligands (CXCLs) are important regulators of tumor progression in many cancers and could serve as potential cancer biomarkers. However, the expression patterns as well as functions of CXCLs remain unclear in penile cancer (PC). The aim of this study was to evaluate the usefulness of serum CXCL13 as a potential cancer biomarker for PC.

Patients and methods

This retrospective study enrolled 76 patients diagnosed with PC between 2016 and 2018. Serum CXCL13 level was detected by enzyme-linked immunosorbent assay. Univariable and multivariable Cox regression analyses were conducted to identify the prognostic factors that influence disease-free survival. Human penile cancer cell lines Penl1, Penl2, 149RCa and LM156 were used as in vitro models. Th

SUBMITTER: Mo M 

PROVIDER: S-EPMC7473990 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature