Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells.

ABSTRACT: During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated with effector functions. Here, we found in vivo activation of NK cells during Listeria monocytogenes infection-augmented transcription of genes encoding mitochondria-associated proteins in a manner dependent on the transcriptional coactivator PGC-1α. Using an Ncr1^Cre-based conditional knockout mouse, we found that PGC-1α was crucial for optimal NK cell effector functions and bioenergetics, as the deletion of PGC-1α was associated with decreased cytotoxic potential and cytokine production along with altered ADP/ATP ratios. Lack of PGC-1α also significantly impaired the ability of NK cells to contr

SUBMITTER: Gerbec ZJ 

PROVIDER: S-EPMC7474003 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature