Mesenchymal Stem Cell Therapy in Chondral Defects of Knee: Current Concept Review.

ABSTRACT:

Purpose

Full-thickness cartilage defects if left alone would increase the risk of osteoarthritis (OA) with severe associated pain and functional disability. Articular cartilage defect may result from direct trauma or chronic degeneration. The capability of the mesenchymal stem cells (MSCs) to repair and regenerate cartilage has been widely investigated. This review describes current trends in MSC biology, the sourcing, expansion, application and role of MSCs in chondral defects of human knees.

Methods

The studies referencing MSCs and knee osteoarthritis were searched (from1998 to 2020) using PubMed, EMBASE, Cochrane Library, Web of Science and the ClinicalTrials.gov with keywords (MSCs, chondral defects or cartilage degeneration of knee, cartilage regeneration, chondrogenesi

SUBMITTER: Debnath UK 

PROVIDER: S-EPMC7474009 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature