Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction.

ABSTRACT: Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (N_cases = 270/N_controls = 5,263) and identified and replicated an association of rs12740679 at chromosome 1q21.2 (P_{discovery+replication} = 2.19 × 10^-12, OR = 1.8) influencing ADAMTSL4 expression. Meta-analysis of discovery and replication samples identified associations with P < 5 × 10^-8 at chromosome 6p24.1 in PHACTR1, chromosome 12q13.3 in LRP1, and in females-only, at chromosome 21q22.11 near LINC00310. A polygenic risk score for SCAD was associated with (1) higher risk of SCAD in individuals with fibromuscular dysplasia (P = 0.021, OR = 1.82 [95% C

SUBMITTER: Saw J 

PROVIDER: S-EPMC7474092 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature