Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors.

ABSTRACT:

Background & aims

Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α⁺ cells (PDGFRα⁺ cells), which are electrically coupled and operate together as the SIP syncytium. PDGFRα⁺ cells have enriched expression of small conductance Ca²⁺-activated K⁺ (SK) channels. Purinergic enteric neural input activates SK channels in PDGFRα⁺ cells, hyperpolarizes SMC, and inhibits colonic contractions. Recently we discovered that PDGFRα⁺ cells in mouse colon have enriched expression of α1A adrenoceptors (ARs), which coupled to activation of SK channels and inhibited colonic motility, and α1A ARs were principal targets for sympathetic regulat

SUBMITTER: Kurahashi M 

PROVIDER: S-EPMC7474159 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature