Altered endothelial ET_B receptor expression in postmenopausal women.

ABSTRACT: The endothelin system plays an important role in mediating vascular function. The endothelin-B receptor (ET_BR) on endothelial cells mediates vasodilation via nitric oxide production. The vasodilatory effect of the ET_BR is lost following menopause and may contribute to impaired vascular endothelial function in postmenopausal women (PMW). However, it is unclear if these functional changes are due to changes in ET_BR expression on the endothelium. Therefore, the purpose of this study was to test the hypothesis that endothelial cell ET_BR expression is lower in PMW compared with young women (YW). Primary endothelial cells were harvested from the antecubital vein of healthy PMW (n = 15, 60 ± 6 yr) and YW (n = 15, 22 ± 2 yr). Cells were ide

SUBMITTER: Kuczmarski AV 

PROVIDER: S-EPMC7474436 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature