Cdc48 cofactor Shp1 regulates signal-induced SCF^Met30 disassembly.

ABSTRACT: Organisms can adapt to a broad spectrum of sudden and dramatic changes in their environment. These abrupt changes are often perceived as stress and trigger responses that facilitate survival and eventual adaptation. The ubiquitin-proteasome system (UPS) is involved in most cellular processes. Unsurprisingly, components of the UPS also play crucial roles during various stress response programs. The budding yeast SCF^Met30 complex is an essential cullin-RING ubiquitin ligase that connects metabolic and heavy metal stress to cell cycle regulation. Cadmium exposure results in the active dissociation of the F-box protein Met30 from the core ligase, leading to SCF^Met30 inactivation. Consequently, SCF^Met30 substrate ubiquitylation is blocked and triggers a downstre

SUBMITTER: Lauinger L 

PROVIDER: S-EPMC7474596 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature