Defined microbiota transplant restores Th17/RORγt⁺ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas.

ABSTRACT: The building evidence for the contribution of microbiota to human disease has spurred an effort to develop therapies that target the gut microbiota. This is particularly evident in inflammatory bowel diseases (IBDs), where clinical trials of fecal microbiota transplantation have shown some efficacy. To aid the development of novel microbiota-targeted therapies and to better understand the biology underpinning such treatments, we have used gnotobiotic mice to model microbiota manipulations in the context of microbiotas from humans with inflammatory bowel disease. Mice colonized with IBD donor-derived microbiotas exhibit a stereotypical set of phenotypes, characterized by abundant mucosal Th17 cells, a deficit in the tolerogenic RORγt⁺ regulatory T (Treg) cell subset, and suscepti

SUBMITTER: Britton GJ 

PROVIDER: S-EPMC7474624 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature