Immune signatures of prodromal multiple sclerosis in monozygotic twins.

ABSTRACT: The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology approach covering a broad range of adaptive and innate immune populations on the protein level. Despite disease discordance, the immune signatures of MS-affected and unaffected cotwins were remarkably similar. Twinship alone contributed 56% of the immune variation, whereas MS explained 1 to 2% of the immune variance. Notably, distinct traits in CD4⁺ effector T cell subsets e

SUBMITTER: Gerdes LA 

PROVIDER: S-EPMC7474627 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature