Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer.

ABSTRACT: We tested cis-Apc^Δ716/Smad4^+/- and cis-Apc^Δ716/Smad4^+/-Kras^G12D mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in cis-Apc^Δ716/Smad4^+/-Kras^G12D mice, although highly aggressive, were suppressed by anti-VEGF treatment. We tested the hypothesis that inflammation, a major risk factor and trigger for CRC, may affect responsiveness to anti-VEGF. Chemically induced colitis (CIC) in cis-Apc^Δ716/Smad4^+/- and cis-

SUBMITTER: Itatani Y 

PROVIDER: S-EPMC7474657 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature