Bacteria- and temperature-regulated peptides modulate β-catenin signaling in Hydra.

ABSTRACT: Animal development has traditionally been viewed as an autonomous process directed by the host genome. But, in many animals, biotic and abiotic cues, like temperature and bacterial colonizers, provide signals for multiple developmental steps. Hydra offers unique features to encode these complex interactions of developmental processes with biotic and abiotic factors, and we used it here to investigate the impact of bacterial colonizers and temperature on the pattern formation process. In Hydra, formation of the head organizer involves the canonical Wnt pathway. Treatment with alsterpaullone (ALP) results in acquiring characteristics of the head organizer in the body column. Intriguingly, germfree Hydra polyps are significantly more sensitive to ALP compared to control p

SUBMITTER: Taubenheim J 

PROVIDER: S-EPMC7474684 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature