Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.

ABSTRACT:

Objective

Esophageal cancer (ESCC) is reported to be the eighth most common malignant tumors worldwide with high mortality. However, the functions of majority circRNAs in ESCC requires to be further explored.

Methods

This study identified differently expressed circRNAs in 3 paired ESCC using RNA-sequencing method. The interactions among circRNAs, miRNAs, and mRNAs were predicted using bioinformatics analysis.

Results

In this study, using RNA-sequencing method and integrated bioinformatics analysis, 418 overexpressed circRNAs and 637 reduced circRNAs in ESCC sample were identified. Based on the mechanism that circRNAs could play as ceRNAs to modulate targets expression, circRNA-miRNA and circRNA-miRNA-mRNA networks were constructed in this study. Based on the network a

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7474783 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature