The kinetics of viral load and antibodies to SARS-CoV-2.

ABSTRACT:

Objectives

The aim was to understand persistence of the virus in body fluids the and immune response of an infected host to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), an agent of coronavirus disease 2019 (COVID-19).

Methods

We determined the kinetics of viral load in several body fluids through real time reverse transcription polymerase chain reaction, serum antibodies of IgA, IgG and IgM by enzyme-linked immunosorbent assay and neutralizing antibodies by microneutralization assay in 35 COVID-19 cases from two hospitals in Guangdong, China.

Results

We found higher viral loads and prolonged shedding of virus RNA in severe cases of COVID-19 in nasopharyngeal (1.3 × 10⁶ vs 6.4 × 10⁴, p < 0.05; 7∼8 weeks) and throat (6.9 × 10⁶

SUBMITTER: Sun J 

PROVIDER: S-EPMC7474805 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature