Expression profile analysis to predict potential biomarkers for glaucoma: BMP1, DMD and GEM.

ABSTRACT:

Purpose

Glaucoma is the second commonest cause of blindness. We assessed the gene expression profile of astrocytes in the optic nerve head to identify possible prognostic biomarkers for glaucoma.

Method

A total of 20 patient and nine normal control subject samples were derived from the GSE9944 (six normal samples and 13 patient samples) and GSE2378 (three normal samples and seven patient samples) datasets, screened by microarray-tested optic nerve head tissues, were obtained from the Gene Expression Omnibus (GEO) database. We used a weighted gene coexpression network analysis (WGCNA) to identify coexpressed gene modules. We also performed a functional enrichment analysis and least absolute shrinkage and selection operator (LASSO) regression analysis. Genes expression was rep

SUBMITTER: Zhang DW 

PROVIDER: S-EPMC7474882 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature