Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial.

ABSTRACT:

Purpose

We hypothesized that neurally adjusted ventilatory assist (NAVA) compared to conventional lung-protective mechanical ventilation (MV) decreases duration of MV and mortality in patients with acute respiratory failure (ARF).

Methods

We carried out a multicenter, randomized, controlled trial in patients with ARF from several etiologies. Intubated patients ventilated for ≤ 5 days expected to require MV for ≥ 72 h and able to breathe spontaneously were eligible for enrollment. Eligible patients were randomly assigned based on balanced treatment assignments with a computerized randomization allocation sequence to two ventilatory strategies: (1) lung-protective MV (control group), and (2) lung-protective MV with NAVA (NAVA group). Allocation concealment was maintained at al

SUBMITTER: Kacmarek RM 

PROVIDER: S-EPMC7474954 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature