Preclinical Single Photon Emission Computed Tomography of Alpha Particle-Emitting Radium-223.

ABSTRACT: Objective: Dose optimization and pharmacokinetic evaluation of α-particle emitting radium-223 dichloride (²²³RaCl₂) by planar γ-camera or single photon emission computed tomography (SPECT) imaging are hampered by the low photon abundance and injected activities. In this study, we demonstrate SPECT of ²²³Ra using phantoms and small animal in vivo models. Methods: Line phantoms and mice bearing ²²³Ra were imaged using a dedicated small animal SPECT by detecting the low-energy photon emissions from ²²³Ra. Localization of the therapeutic agent was verified by whole-body and whole-limb autoradiography and its radiobiological effect confirmed by immunofluorescence. Results: A state-of-the-art

SUBMITTER: Abou DS 

PROVIDER: S-EPMC7475100 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature