Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy.

ABSTRACT:

Objective

The Vitamin D receptor (VDR) has been positively associated with skeletal muscle mass, function and regeneration. Mechanistic studies have focused on the loss of the receptor, with in vivo whole-body knockout models demonstrating reduced myofibre size and function and impaired muscle development. To understand the mechanistic role upregulation of the VDR elicits in muscle mass/health, we studied the impact of VDR over-expression (OE) in vivo before exploring the importance of VDR expression upon muscle hypertrophy in humans.

Methods

Wistar rats underwent in vivo electrotransfer (IVE) to overexpress the VDR in the Tibialis anterior (TA) muscle for 10 days, before comprehensive physiological and metabolic profiling to characterise the influence of VDR-OE on muscle pr

SUBMITTER: Bass JJ 

PROVIDER: S-EPMC7475200 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature