Post direct acting anti-viral agents associated primary hepatic Castleman's disease: A case report.

ABSTRACT: Castleman's disease (CD) is a primary lymphoproliferative disorder of the lymph nodes with rare extra-nodal primary affection.

Presentation of case

Here we present a case of primary hepatic CD associated with hepatocellular carcinoma (HCC).

Discussion

Sixty-two years old, male received direct-acting antiviral agents (DAAs) for HCV infection. Follow up revealed sustained virologic response; however, three hepatic focal lesions were accidently discovered. Triphasic CT confirmed the HCC nature of two masses while the other mass remained undiagnosed. Surgical intervention was the treatment of choice, and pathological examination showed a fairly circumscribed mass formed of angiolymphoid hyperplasia displayed atrophic germinal center, expanded mantle zone, and variable hyalinizati

SUBMITTER: Sweed D 

PROVIDER: S-EPMC7475233 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature