Clinical relevance of cancer stem cell chemotherapeutic assay for recurrent ovarian cancer.

ABSTRACT:

Introduction

Disease recurrence and progression of ovarian cancer is common with the development of platinum-resistant or refractory disease. This is due in large part to the presence of chemo-resistant cancer stem cells (CSCs) that contribute to tumor propagation, maintenance, and treatment resistance. We developed a CSCs drug cytotoxicity assay (ChemoID) to identify the most effective chemotherapy treatment from a panel of FDA approved chemotherapies.

Methods

Ascites and pleural fluid samples were collected under physician order from 45 consecutive patients affected by 3rd-5th relapsed ovarian cancer. Test results from the assay were used to treat patients with the highest cell kill drugs, taking into consideration their health status and using dose reductions, as needed.

SUBMITTER: Howard CM 

PROVIDER: S-EPMC7475270 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature