ADNCR modulates neural stem cell differentiation and proliferation through the regulation of TCF3 expression.

ABSTRACT:

Background

Neural stem cells (NSCs) are undifferentiated precursor cells that have the ability to self-renew and proliferate and have the capacity to become either glia (oligodendrocytes and astrocytes) or neurons. NSCs can act as beneficial adjuncts for many neurological disorders, such as cerebral infarction, spinal cord injuries, Alzheimer's disease, and Parkinson's disease. Long noncoding RNAs (lncRNAs) play essential roles during cell differentiation, proliferation, and metabolism. This study aimed to explore the role played by adipocyte differentiation-associated long noncoding RNA (ADNCR) in the self-renewal and multipotency of NSCs.

Methods

In this study, we identified NSCs and verified that these cells were able to regenerate and differentiate into both astrocytes a

SUBMITTER: Long L 

PROVIDER: S-EPMC7475390 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature