Intensity-modulated particle beam radiation therapy in the management of olfactory neuroblastoma.

ABSTRACT:

Background

To report the clinical experience and short-term efficacy in the management of olfactory neuroblastoma (ONB).

Methods

We performed a retrospective analysis of 12 ONB patients treated with particle beam radiation therapy (PBRT) between 12/2015 and 5/2019 at the Shanghai Proton and Heavy Ion Center. Four (33.3%) patients presented with Kadish B ONB, and 8 (66.7%) presented with Kadish C or D disease. Eleven patients received proton radiotherapy (PRT) followed by a carbon ion radiotherapy (CIRT) boost, one patient received CIRT only. The 2-year survival rates were calculated using the Kaplan-Meier method. Acute and late adverse events were summarized and scored according to the CTCAE (version 4.03).

Results

With a median follow-up of 17.5 (range, 2.53-49.9) mo

SUBMITTER: Hu W 

PROVIDER: S-EPMC7475427 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature