Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice.

ABSTRACT:

Background

Mental stress mainly induces depression, and predictable stress, as well as a constant bombardment of chronic unpredictable micro-stressors, always coexist in daily life. However, the combined effect of predictable and unpredictable stress on depression is still not fully understood.

Methods

The chronic restraint stress (CRS) is to restrain the mice for 6 h per day for 3 weeks, and the chronic unpredictable mild stress (CUMS) is to stimulate the mice with 7 different stressors for 3 weeks. We evaluated the combined effect of CRS and CUMS on depression-like symptoms using behavioral tests and investigated the action mechanism through analysis of neurotransmitters, brain-derived factors, inflammatory factors, antioxidants, and intestinal microorganisms.

Results</

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC7475446 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature