Spliceosome-associated protein 130: a novel biomarker for idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Spliceosome-associated protein 130 (SAP130), a novel danger-associated molecular pattern (DAMP), is involved in inflammatory disease. However, no data are available about SAP130 in idiopathic pulmonary fibrosis (IPF). Our study aimed to investigate SAP130 in the serum and lung tissue of patients with IPF and to determine its clinical significance.

Methods

SAP130 levels in the serum of 83 IPF patients and 38 healthy subjects were measured. Additionally, immunohistochemical staining for SAP130 was performed in lung specimens of IPF patients and control subjects. Correlation between serum SAP130 levels and clinical parameters were investigated.

Results

Serum SAP130 levels were elevated in IPF patients compared with healthy controls. In parallel, the expression

SUBMITTER: Liu K 

PROVIDER: S-EPMC7475450 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature