Improved osteogenic activity and inhibited bacterial biofilm formation on andrographolide-loaded titania nanotubes.

ABSTRACT:

Background

Delivery of local drugs with a titania nanotube is an attractive approach to combat implant-related infection. Our earlier study has confirmed that nanotubes loaded with gentamicin could significantly improve the antibacterial ability. On this basis, the used andrographolide in this paper has a high antibacterial activity, which cannot only avoid the evolution of antibiotic-resistant bacteria but also has simultaneously excellent biocompatibility with osteogenic cells.

Methods

Two mg of andrographolide was loaded into titania nanotubes, which were fabricated into different diameters (50 and 100 nm) and 200 nm length by the method of lyophilization and vacuum drying. We chose a standard strain, Staphylococcus epidermidis (American Type Culture Collection 35984), an

SUBMITTER: Feng E 

PROVIDER: S-EPMC7475475 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature