Dysregulated plasma levels of miRNA-132 and miRNA-134 in patients with obsessive-compulsive disorder.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is a severe, chronic, disabling neuropsychiatric disorder, the pathophysiology of which has yet to be fully understood. In this study, we aimed to detect the levels of miRNA-132 and miRNA-134 in the plasma of patients with OCD and to analyze the factors influencing OCD.

Methods

The levels of miRNA-132 and miRNA-134 in peripheral blood of 30 patients with OCD and 32 normal controls were detected by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Patients were assessed using clinical scales, including the Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).

Results

The plasma levels of miRNA-132 and miRNA 134 in the OCD gro

SUBMITTER: Yue J 

PROVIDER: S-EPMC7475501 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature