Nonalcoholic fatty liver disease impacts the control of the international normalized ratio in patients with atrial fibrillation.

ABSTRACT:

Background

It is unclear whether the therapeutic effect of warfarin in patients with atrial fibrillation (AF) and normal liver function differs between those with and without nonalcoholic fatty liver disease (NAFLD). With this in mind, we aimed to evaluate the impact of NAFLD on the international normalized ratio (INR) control in warfarin-treated AF patients with normal liver function.

Methods

We enrolled 600 AF patients aged 28-94 (median 68) with normal liver function who were receiving daily warfarin therapy, 172 with NAFLD and 428 without. The INR and INR/warfarin dosage rate were measured. Four nested multivariable linear regression models adjusted for potential confounders were used to assess whether there were differences in INR and INR/warfarin dose rate between pati

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7475506 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature