Cholinergic muscarinic M₁/M₄ receptor networks in dementia with Lewy bodies.

ABSTRACT: Cholinergic dysfunction is central in dementia with Lewy bodies, possibly contributing to the cognitive and psychiatric phenotypes of this condition. We investigated baseline muscarinic M₁/M₄ receptor spatial covariance patterns in dementia with Lewy bodies and their association with changes in cognition and neuropsychiatric symptoms after 12 weeks of treatment with the cholinesterase inhibitor donepezil. Thirty-eight participants (14 cholinesterase inhibitor naive patients, 24 healthy older individuals) underwent ¹²³I-iodo-quinuclidinyl-benzilate (M₁/M₄ receptor assessment) and ^99mTc-exametazime (perfusion) single-photon emission computed tomography scanning. We implemented voxel principal components analysis, producing a s

SUBMITTER: Colloby SJ 

PROVIDER: S-EPMC7475694 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature