Anti-Cancer Effects of Lycopene in Animal Models of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Globally, hepatocellular carcinoma (HCC) is the sixth most diagnosed cancer and the third important cause of cancer-related death. As there are only two targeted drugs for the treatment of advanced HCC-that merely extend survival by a few months-the need for alternative treatments is inevitable. Lycopene, a carotenoid that is known to be most abundant in red tomatoes and tomato-based products, has been investigated for its anticancer activity in various types of cancers including HCC. This review was conducted to evaluate the effects of lycopene on HCC from animal models to pave the way for further clinical studies.

Methods

Electronic databases and search engines including PubMed, EMBASE, and Google Scholar were searched for original records addressing the antic

SUBMITTER: Mekuria AN 

PROVIDER: S-EPMC7475703 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature