Bioinformatic Analysis of Neuroimmune Mechanism of Neuropathic Pain.

ABSTRACT:

Background

Neuropathic pain (NP) is a devastating complication following nerve injury, and it can be alleviated by regulating neuroimmune direction. We aimed to explore the neuroimmune mechanism and identify some new diagnostic or therapeutic targets for NP treatment via bioinformatic analysis.

Methods

The microarray GSE18803 was downloaded and analyzed using R. The Venn diagram was drawn to find neuroimmune-related differentially expressed genes (DEGs) in neuropathic pain. Gene Ontology (GO), pathway enrichment, and protein-protein interaction (PPI) network were used to analyze DEGs, respectively. Besides, the identified hub genes were submitted to the DGIdb database to find relevant therapeutic drugs.

Results

A total of 91 neuroimmune-related DEGs were identified. T

SUBMITTER: Yu H 

PROVIDER: S-EPMC7475749 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature