Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance.

ABSTRACT:

Objective

To review the mechanism of action, mechanisms of resistance, in vitro activity, pharmacokinetics, pharmacodynamics, and clinical data for a novel aminoglycoside.

Data sources

A PubMed search was performed from January 2006 to August 2019 using the following search terms: plazomicin and ACHN-490. Another search was conducted on clinicaltrials.gov for published clinical data. References from selected studies were also used to find additional literature.

Study selection and data extraction

All English-language studies presenting original research (in vitro, in vivo, pharmacokinetic, and clinical) were evaluated.

Data synthesis

Plazomicin has in vitro activity against several multi-drug-resistant organisms, including carbapenem-resist

SUBMITTER: Clark JA 

PROVIDER: S-EPMC7475792 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature