Structural Modifications Controlling Membrane Raft Partitioning and Curvature in Human and Viral Proteins.

ABSTRACT: Membrane proteins and lipids have the capacity to associate into lateral domains in cell membranes through mutual or collective interactions. Lipid rafts are functional lateral domains that are formed through collective interactions of certain lipids and which can include or exclude proteins. These domains have been implicated in cell signaling and protein trafficking and seem to be of importance for virus-host interactions. We therefore want to investigate if raft and viral membrane proteins present similar structural features, and how these features are distributed throughout viruses. For this purpose, we performed a bioinformatics analysis of raft and viral membrane proteins from available online databases and compared them to nonraft proteins. In general, transmembrane proteins of raft

SUBMITTER: Yurtsever D 

PROVIDER: S-EPMC7476027 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature