Response to SSRI intervention and amygdala activity during self-referential processing in major depressive disorder.

ABSTRACT: There are conflicting reports on the impact of antidepressants on neural reactions for positive information. We thus hypothesized that there would be clinically important individual differences in neural reactivity to positive information during SSRI therapy. We further predicted that only those who responded to SSRIs would show increased amygdala reactivity to positive information following treatment to a level similar to that seen in healthy participants. Depressed individuals (n = 17) underwent fMRI during performance of a task involving rating the self-relevance of emotionally positive and negative cue words before and after receiving 12 weeks of SSRI therapy. At post-treatment, SSRI responders (n = 11) had increased amygdala activity in response to positive stimuli, and decreased acti

SUBMITTER: Young KD 

PROVIDER: S-EPMC7476063 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature