Cell-free fat extract accelerates diabetic wound healing in db/db mice.

ABSTRACT: Cell-free fat extract (CEFFE), the liquid fraction derived from fat tissues, is enriched with a variety of growth factors and possesses pro-angiogenic, anti-apoptotic, and anti-oxidative properties. The aim of this study was to determine if CEFFE could accelerate chronic wound healing in mice with diabetes and investigate its underlying mechanisms. A model of circular full-thickness wound (6 mm diameter) was produced in the central dorsal region of spontaneous type 2 diabetes mellitus db/db mice. The mice were divided to three groups depending on dosage of CEFFE administered for the study; high dose CEFFE group (CEFFE^high; administered 2.5 ml/kg/day via subcutaneous injection for six days), low dose CEFFE group (CEFFE^low; administered 2.5 ml/kg/day via subcutaneous in

SUBMITTER: Wang X 

PROVIDER: S-EPMC7476113 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature