Developing knowledge-based planning for gynaecological and rectal cancers: a clinical validation of RapidPlan^™.

ABSTRACT:

Introduction

To create and clinically validate knowledge-based planning (KBP) models for gynaecologic (GYN) and rectal cancer patients. Assessment of ecologic generalisability and predictive validity of conventional planning versus single calculation KBP was reviewed against practical metrics of planning time (PT) and radiation oncologist plan preference.

Method

Study cohorts were 34 and 42 consecutively treated GYN and rectal cancer patients dosimetrically archived within the centre's research databank. For model training, structures and dose distributions from 22 and 32 GYN and rectal volumetric-modulated arc therapy (VMAT) plans were used in RapidPlan™. Prescription doses ranged from 45 to 60Gy in 25 fractions using a simultaneous integrated boost to 2-4 targets and up to

SUBMITTER: Shepherd M 

PROVIDER: S-EPMC7476182 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature