High-Dimensional Analysis of Postsplenectomy Peripheral Immune Cell Changes.

ABSTRACT: Although the consequences of splenectomy are well understood in mice, much less is known about the immunologic changes that occur following splenectomy in humans. We sought to characterize the circulating immune cell populations of patients before and after elective splenectomy to determine if these changes are related to postsplenectomy survival outcomes. Retrospective clinical information was collected from 95 patients undergoing elective splenectomy compared with 91 patients undergoing pancreaticoduodenectomy (Whipple procedure). We further analyzed peripheral blood from five patients in the splenectomy group, collected before and after surgery, using single-cell cytometry by time-of-flight mass spectrometry. We compared pre- and postsplenectomy data to characterize both the major and m

SUBMITTER: Borgers JSW 

PROVIDER: S-EPMC7476217 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature