Different cytokine patterns associate with melancholia severity among inpatients with major depressive disorder.

ABSTRACT:

Background

Six melancholic features (MFs) of the Hamilton Depression Rating Scale (HAM-D₆) represent the construct of melancholia along a continuum of severity (from least to most severe: depressed mood, work and activities, somatic symptoms, psychic anxiety, guilty feelings, psychomotor retardation). We aimed to evaluate the association between these MFs and inflammatory cytokines (IC) in the blood.

Methods

Each IC [interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, IL-10, and IL-17] was associated with the HAM-D₆ MFs of 139 severely depressed inpatients, using multiple linear regressions adjusted for covariates. Levels were compared with those of 100 healthy controls.

Results

Depressed mood was asso

SUBMITTER: Primo de Carvalho Alves L 

PROVIDER: S-EPMC7476328 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature