Circulating metabolomics profiling reveals novel pathways associated with cognitive decline in patients with hypertension.

ABSTRACT:

Background

Hypertension is a significant risk factor for cardiovascular disease, and it is associated with dementia, including Alzheimer's disease (AD). Although it may be correlated with AD in terms of symptoms, the link between hypertension and AD pathological biomarkers, and the potential underlying mechanism of hypertension with cognitive decline, are still not well understood.

Methods

The Mini-Mental State Examination (MMSE) scores were used to evaluate cognitive function. Enzyme-linked immunosorbent assays were used to examine plasma amyloid-beta (Aβ)₄₀, Aβ₄₂, and tau concentration in hypertensive patients. Metabolomics and metagenomics were performed to identify the significantly changed circulating metabolites and microbiota between healthy indi

SUBMITTER: Huang Y 

PROVIDER: S-EPMC7476355 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature