Wnt-Notch Signaling Interactions During Neural and Astroglial Patterning of Human Stem Cells.

ABSTRACT: The human brain formation involves complicated processing, which is regulated by a gene regulatory network influenced by different signaling pathways. The cross-regulatory interactions between elements of different pathways affect the process of cell fate assignment during neural and astroglial tissue patterning. In this study, the interactions between Wnt and Notch pathways, the two major pathways that influence neural and astroglial differentiation of human induced pluripotent stem cells (hiPSCs) individually, were investigated. In particular, the synergistic effects of Wnt-Notch pathway on the neural patterning processes along the anterior-posterior or dorsal-ventral axis of hiPSC-derived cortical spheroids were explored. The human cortical spheroids derived from hiPSCs were treated wit

SUBMITTER: Bejoy J 

PROVIDER: S-EPMC7476393 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature