Ontology highlight
ABSTRACT:
SUBMITTER: Sen S
PROVIDER: S-EPMC7476413 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Cold Spring Harbor molecular case studies 20200825 4
Although BRAF inhibition has demonstrated activity in <i>BRAF</i><sup><i>V600</i></sup> -mutated brain tumors, ultimately these cancers grow resistant to BRAF inhibitor monotherapy. Parallel activation of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway has been implicated as a mechanism of primary and secondary resistance to BRAF inhibition. Moreover, it has been shown specifically that mTOR signaling activation occurs in BRAF-mutant brain tumors. We therefore conducted p ...[more]