Comprehensive miRNA Analysis Using Serum From Patients With Noninfectious Uveitis.

ABSTRACT:

Purpose

MicroRNAs (miRNAs) are noncoding RNAs and have attracted attention as a biomarker in a variety of diseases. However, extensive unbiased miRNAs analysis in patients with uveitis has not been completely explored. In the present study, we comprehensively analyzed the deregulated miRNAs in three major forms of uveitis (Behҫet's disease [BD], sarcoidosis and Vogt-Koyanagi-Harada disease [VKH]) to search for potential biomarkers.

Methods

This study included 10 patients with BD, 17 patients with sarcoidosis, and 13 patients with VKH. Eleven healthy subjects were used as controls. The miRNAs expression levels were studied by microarray using serum samples from patients with uveitis and healthy controls.

Results

A total of 281 upregulated miRNAs and 137 downregulated m

SUBMITTER: Asakage M 

PROVIDER: S-EPMC7476662 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature