Sequencing for an interdisciplinary molecular tumor board in patients with advanced breast cancer: experiences from a case series.

ABSTRACT:

Purpose

High throughput panel sequencing to tailor therapy in precision oncology promises to improve outcome in patients with metastatic breast cancer. However, data that clearly show any benefit from such an approach is still pending.

Materials and methods

We performed a retrospective analysis of advanced breast cancer patients that underwent panel sequencing for suggestion of target related drugs. We aimed to (i) determine the frequency of actionable mutations per patient and to (ii) assess the clinical impact of results on treatment options.

Results

A total of 52 patients underwent panel sequencing of archived tumor tissue. Every sample showed at least one affected gene, accounting for actionable mutations in 45 of 52 patients (87%). New treatment options that woul

SUBMITTER: Walter C 

PROVIDER: S-EPMC7476733 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature