Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

ABSTRACT: Studies in humans and animals have demonstrated that infection with helminths (parasitic worms) is protective against a range of hyperinflammatory diseases. A number of factors limit translation into clinical use, including: potential contamination of helminths obtained from infected humans or animals, lack of batch to batch stability, and potential pathological risks derived from live worm infections. To overcome these limitations we tested whether an antigen homogenate of the non-pathogenic nematode Caenorhabditis elegans confers protection against type 1 diabetes mellitus (T1D) using the Non Obese Diabetic (NOD) mouse model. Our study demonstrates that twice weekly intraperitoneal injections of axenically cultured C. elegans antigen (aCeAg) confers substantial protection a

SUBMITTER: Jackson-Thompson BM 

PROVIDER: S-EPMC7476867 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature