Synergy Screening Identifies a Compound That Selectively Enhances the Antibacterial Activity of Nitric Oxide.

ABSTRACT: Antibiotic resistance poses a serious threat to global health. To reinforce the anti-infective arsenal, many novel therapeutic strategies to fight bacterial infections are being explored. Among them, anti-virulence therapies, which target pathways important for virulence, have attracted much attention. Nitric oxide (NO) defense systems have been identified as critical for the pathogenesis of various bacteria, making them an appealing therapeutic target. In this study, we performed chemical screens to identify inhibitors of NO detoxification in Escherichia coli. We found that 2-mercaptobenzothiazole (2-MBT) can potently inhibit cellular detoxification of NO, achieving a level of inhibition that resembled the effect of genetically removing Hmp, the dominant detoxification enzyme under

SUBMITTER: Chou WK 

PROVIDER: S-EPMC7477088 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature