A Preliminary Study of the Association between SOX17 Gene Variants and Intracranial Aneurysms Using Exome Sequencing.

ABSTRACT:

Objective

Conflicting results regarding SOX17 genes and the risk of intracranial aneurysms (IA) exist in the Korean population, although significant positive correlations were noted in genome-wide association studies in European and Japanese populations. Therefore, we aimed to investigate an association between SOX17 gene variants and IA using exome sequencing data.

Methods

This study included 26 age-gender matched IA patients and 26 control subjects. The SOX17 gene variants identified from whole-exome sequencing data were examined. Genetic associations to estimate odds ratio (OR) and 95% confidence interval (CI) were performed using the software EPACTS.

Results

The mean age of the IA and control groups were 51.0±9.3 years and 49.4±14.3 years, respectively (p=0.623).

SUBMITTER: Park JJ 

PROVIDER: S-EPMC7477156 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature