Charge-switch derivatization of fatty acid esters of hydroxy fatty acids via gas-phase ion/ion reactions.

ABSTRACT: Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of endogenous bioactive lipids with anti-diabetic and anti-inflammatory effects. Identification of FAHFAs is challenging due to both the relatively low abundance of these metabolites in most biological samples and the significant structural diversity arising from the co-occurrence of numerous regioisomers. Ultimately, development of sensitive analytical techniques that enable rapid and unambiguous identification of FAHFAs is integral to understanding their diverse physiological functions in health and disease. While a battery of mass spectrometry (MS) based methods for complex lipid analysis has been developed, FAHFA identification presents specific challenges to conventional approaches. Notably, whi

SUBMITTER: Randolph CE 

PROVIDER: S-EPMC7477303 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature