Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells.

ABSTRACT: Mesenchymal stromal cells (MSCs) hold great therapeutic potential, in part because of their immunomodulatory properties. However, these properties can be transient and depend on multiple factors. Here, we developed a multifunctional hydrogel system to synergistically enhance the immunomodulatory properties of MSCs, using a combination of sustained inflammatory licensing and three-dimensional (3D) encapsulation in hydrogels with tunable mechanical properties. The immunomodulatory extracellular matrix hydrogels (iECM) consist of an interpenetrating network of click functionalized-alginate and fibrillar collagen, in which interferon γ (IFN-γ) loaded heparin-coated beads are incorporated. The 3D microenvironment significantly enhanced the expression of a wide panel of pivotal immunomodulatory

SUBMITTER: Gonzalez-Pujana A 

PROVIDER: S-EPMC7477339 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature