Mechanisms and Pharmacotherapy for Ethanol-Responsive Movement Disorders.

ABSTRACT: Ethanol-responsive movement disorders are a group of movement disorders of which clinical manifestation could receive significant improvement after ethanol intake, including essential tremor, myoclonus-dystonia, and some other hyperkinesia. Emerging evidence supports that the sensitivity of these conditions to ethanol might be attributed to similar anatomical targets and pathophysiologic mechanisms. Cerebellum and cerebellum-related networks play a critical role in these diseases. Suppression of inhibitory neurotransmission and hyper-excitability of these regions are the key points for pathogenesis. GABA pathways, the main inhibitory system involved in these regions, were firstly linked to the pathogenesis of these diseases, and GABA_A receptors and GABA_B receptors pla

SUBMITTER: Wu J 

PROVIDER: S-EPMC7477383 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature