Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes.

ABSTRACT:

Aims

To clarify the clinical impact of pancreatic fat volume on beta cell function in type 2 diabetes patients.

Materials and methods

One hundred thirty two consecutive type 2 diabetic patients (mean age, 63.7 years) were enrolled in this cross-sectional study. Total pancreatic volume (TPV), pancreatic fat volume (PFV), and pancreatic parenchymal volume (PPV), and visceral fat volume were examined quantitatively with multidetector computed tomography using SYNAPSE VINCENT image analysis system (Fujifilm Inc., Tokyo, Japan). Pancreatic fat was identified using Hounsfield Units of less than zero. The capacity of insulin secretion was assessed by C-peptide immunoreactivity (CPR) index (100 × fasting CPR/fasting plasma glucose). Insulin sensitivity was evaluated using CPR-insuli

SUBMITTER: Fukase A 

PROVIDER: S-EPMC7477536 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature